The zine typically included personal essays and/or journal entries, in addition to book and zine reviews. Some examples of subject coverage include veganism, librarianship, cycling, running, and nature. Covers of the zine usually featured screen printed or linoleum block printed artwork.
Issues of Thoughtworm have been featured in exhibitions at SPACES Gallery in Cleveland, OH. Issues 7, 8 and 9 were chosen for the 2003 tour of North America by Mobilivre-Bookmobile, the travelling library of independent publications.